EFEKTIVITAS PENGGUNAAN METAMIZOL DENGAN KOMBINASI METAMIZOL-VITAMIN B SEBAGAI PEREDA NYERI PADA PASIEN LANSIA DIABETES MELITUS TIPE-II DI RUMAH SAKIT “X” KOTA BATU PERIODE 2023-2025

ABSTRAK
Latar belakang: Nyeri neuropati diabetik pada pasien diabetes melitus tipe-II sering memerlukan terapi analgesik yang efektif. Metamizol digunakan sebagai analgesik, dan vitamin B kerap ditambahkan sebagai terapi adjuvan untuk mendukung fungsi saraf. Tujuan: Membandingkan efektivitas metamizol monoterapi dengan metamizol kombinasi vitamin B terhadap penurunan intensitas nyeri pada pasien lansia dengan diabetes melitus tipe-II. Metode: Studi observasional analitik dengan desain cross-sectional menggunakan data sekunder rekam medis pasien rawat inap di Rumah Sakit X Kota Batu periode Desember 2023–Desember 2025. Sampel diambil dengan purposive sampling sebanyak 60 pasien, terdiri atas 30 pasien kelompok monoterapi dan 30 pasien kelompok kombinasi vitamin B. Data dianalisis secara univariat dan bivariat menggunakan uji Shapiro-Wilk, Mann-Whitney U, dan Independent Samples T-Test. Hasil: Menunjukkan rerata penurunan skala nyeri pada kelompok metamizol monoterapi sebesar 4,60 dan pada kelompok kombinasi vitamin B sebesar 4,83. Namun, perbedaan tersebut tidak bermakna secara statistik (p=0,601). Lama rawat inap juga tidak berbeda bermakna antara kedua kelompok (p=0,250). Kesimpulan: Penambahan vitamin B pada metamizol injeksi belum menunjukkan efektivitas analgesik yang lebih baik dibandingkan metamizol monoterapi pada pasien lansia dengan diabetes melitus tipe-II.

Kata Kunci: metamizol, vitamin B, nyeri neuropati, diabetes melitus, lansia

ABSTRACT
Background: Diabetic neuropathic pain in patients with type-II diabetes mellitus often requires effective analgesic therapy. Metamizole is commonly used as an analgesic, while vitamin B is frequently administered as an adjuvant therapy to support nerve function. Objective: To compare the effectiveness of metamizole monotherapy with metamizole combined with vitamin B in reducing pain intensity among elderly patients with type-II diabetes mellitus. Methods: This analytical observational study employed a cross-sectional design using secondary data obtained from the medical records of hospitalized patients at Hospital X, Batu City, Indonesia, between December 2023 and December 2025. A total of 60 eligible patients were selected through purposive sampling, comprising 30 patients who received metamizole monotherapy and 30 patients who received metamizole combined with vitamin B. Data were analyzed using univariate and bivariate statistical methods, including the Shapiro–Wilk test, Mann–Whitney U test, and Independent Samples t-test. Results: The mean reduction in pain intensity was 4.60 points in the metamizole monotherapy group and 4.83 points in the metamizole plus vitamin B group. However, the difference between the two groups was not statistically significant (p = 0.601). Likewise, no significant difference was observed in the length of hospital stay between the groups (p = 0.250). Conclusion: The addition of vitamin B to injectable metamizole did not demonstrate superior analgesic effectiveness compared with metamizole monotherapy in elderly patients with type-II diabetes mellitus.

Keywords: metamizole, vitamin B, neuropathic pain, diabetes mellitus, elderly